解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::ModelTest-NG is a reimplementation from scratch of jModelTest and ProtTest, two popular tools for selecting the best-fit nucleotide and amino acid substitution models, respectively. ModelTest-NG is one to two orders of magnitude faster than jModelTest and ProtTest but equally accurate and introduces several new featur...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz189
更新日期:2020-01-01 00:00:00
abstract::Comparing newly obtained and previously known nucleotide and amino-acid sequences underpins modern biological research. BLAST is a well-established tool for such comparisons but is challenging to use on new data sets. We combined a user-centric design philosophy with sustainable software development approaches to crea...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz185
更新日期:2019-12-01 00:00:00
abstract::Some genes have repeatedly been found to control diverse adaptations in a wide variety of organisms. Such gene reuse reveals not only the diversity of phenotypes these unique genes control but also the composition of developmental gene networks and the genetic routes available to and taken by organisms during adaptati...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz194
更新日期:2019-12-01 00:00:00
abstract::Many methods exist for detecting introgression between nonsister species, but the most commonly used require either a single sequence from four or more taxa or multiple sequences from each of three taxa. Here, we present a test for introgression that uses only a single sequence from three taxa. This test, denoted D3, ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz178
更新日期:2019-12-01 00:00:00
abstract::Interbreeding between hatchery-reared and wild fish, through deliberate stocking or escapes from fish farms, can result in rapid phenotypic and gene expression changes in hybrids, but the underlying mechanisms are unknown. We assessed if one generation of captive breeding was sufficient to generate inter- and/or trans...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz135
更新日期:2019-10-01 00:00:00
abstract::Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mutation load. We examine here if artificial selection can counteract the negative...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz148
更新日期:2019-10-01 00:00:00
abstract::Because of the degeneracy of the genetic code, multiple codons are translated into the same amino acid. Despite being "synonymous," these codons are not equally used. Selective pressures are thought to drive the choice among synonymous codons within a genome, while GC content, which is typically attributed to mutation...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz124
更新日期:2019-10-01 00:00:00
abstract::Hybridization and polyploidization are important evolutionary processes whose impacts range from the alteration of gene expression and phenotypic variation to the triggering of asexual reproduction. We investigated fishes of the Cobitis taenia-elongatoides hybrid complex, which allowed us to disentangle the direct eff...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz114
更新日期:2019-09-01 00:00:00
abstract::Gene expression changes contribute to complex trait variations in both individuals and populations. However, the evolution of gene expression underlying complex traits over macroevolutionary timescales remains poorly understood. Snake venoms are proteinaceous cocktails where the expression of each toxin can be quantif...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz125
更新日期:2019-09-01 00:00:00
abstract::Genetic variation in contemporary South Asian populations follows a northwest to southeast decreasing cline of shared West Eurasian ancestry. A growing body of ancient DNA evidence is being used to build increasingly more realistic models of demographic changes in the last few thousand years. Through high-quality mode...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz037
更新日期:2019-08-01 00:00:00
abstract::Inferring past population dynamics over time from heterochronous molecular sequence data is often achieved using the Bayesian Skygrid model, a non-parametric coalescent model that estimates the effective population size over time. Available in BEAST, a cross-platform program for Bayesian analysis of molecular sequence...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz172
更新日期:2019-07-31 00:00:00
abstract::Knowledge of mutation rates is crucial for calibrating population genetics models of demographic history in units of years. However, mutation rates remain challenging to estimate because of the need to identify extremely rare events. We estimated the nuclear mutation rate in wolves by identifying de novo mutations in ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz159
更新日期:2019-07-12 00:00:00
abstract::Serotonin is a neurotransmitter that plays an important role in regulating behavior and personality in humans and other mammals. Polymorphisms in genes coding for the serotonin receptor subtype 1A (HTR1A), the serotonin transporter (SLC6A4), and the serotonin degrading enzyme monoamine oxidase A (MAOA) are associated ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz061
更新日期:2019-07-01 00:00:00
abstract::Despite the importance of plant-plant interactions on plant community dynamics and crop yield, our understanding of the adaptive genetics underlying these interactions is still limited and deserves to be investigated in the context of complex and diffuse interactions occurring in plant assemblages. Here, based on 145 ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz078
更新日期:2019-07-01 00:00:00
abstract::Subspecies nomenclature systems of pathogens are increasingly based on sequence data. The use of phylogenetics to identify and differentiate between clusters of genetically similar pathogens is particularly prevalent in virology from the nomenclature of human papillomaviruses to highly pathogenic avian influenza (HPAI...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz053
更新日期:2019-07-01 00:00:00
abstract::The SLiM forward genetic simulation framework has proved to be a powerful and flexible tool for population genetic modeling. However, as a complex piece of software with many features that allow simulating a diverse assortment of evolutionary models, its initial learning curve can be difficult. Here we provide a step-...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy237
更新日期:2019-05-01 00:00:00
abstract::Epigenetic information, which can be passed on independently of the DNA sequence, is stored in part in the form of histone posttranslational modifications and specific histone variants. Although complexes necessary for deposition have been identified for canonical and variant histones, information regarding the chroma...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz039
更新日期:2019-05-01 00:00:00
abstract::The ribosome is responsible for protein synthesis in all living organisms. It is best known to exist around 3.5-3.7 Ga whereat life on Earth inhabited anoxic environment with abundant soluble irons. The RNAs and proteins are the two biopolymers that constitute the ribosome. However, both proteins and RNAs require meta...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz034
更新日期:2019-05-01 00:00:00
abstract::The emergence of islands has been linked to spectacular radiations of diverse organisms. Although penguins spend much of their lives at sea, they rely on land for nesting, and a high proportion of extant species are endemic to geologically young islands. Islands may thus have been crucial to the evolutionary diversifi...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz017
更新日期:2019-04-01 00:00:00
abstract::With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology. The SLiM forward genetic simulation framework is one of the most powerful and widely used tools in this area. However, its...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy228
更新日期:2019-03-01 00:00:00
abstract::Multipartite genomes, containing at least two large replicons, are found in diverse bacteria; however, the advantage of this genome structure remains incompletely understood. Here, we perform comparative genomics of hundreds of finished β-proteobacterial genomes to gain insights into the role and emergence of multipar...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy248
更新日期:2019-03-01 00:00:00
abstract::Mitochondrial ribosomes (mitoribosomes) are essential components of all mitochondria that synthesize proteins encoded by the mitochondrial genome. Unlike other ribosomes, mitoribosomes are highly variable across species. The basis for this diversity is not known. Here, we examine the composition and evolutionary histo...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy221
更新日期:2019-02-01 00:00:00
abstract::The diploid D-genome lineage of the Triticum/Aegilops complex has an evolutionary history involving genomic contributions from ancient A- and B/S-genome species. We explored here the possible cytonuclear evolutionary responses to this history of hybridization. Phylogenetic analysis of chloroplast DNAs indicates that t...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy215
更新日期:2019-02-01 00:00:00
abstract::The mutational process varies at many levels, from within genomes to among taxa. Many mechanisms have been linked to variation in mutation, but understanding of the evolution of the mutational process is rudimentary. Physiological condition is often implicated as a source of variation in microbial mutation rate and ma...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy213
更新日期:2019-02-01 00:00:00
abstract::It is known that the effective population size (Ne) and the mutation rate (u) vary across the genome. Here, we show that ignoring this heterogeneity may lead to biased estimates of past demography. To solve the problem, we develop new methods for jointly inferring past changes in population size and detecting variatio...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy212
更新日期:2019-02-01 00:00:00
abstract::Variation at the FADS1/FADS2 gene cluster is functionally associated with differences in lipid metabolism and is often hypothesized to reflect adaptation to an agricultural diet. Here, we test the evidence for this relationship using both modern and ancient DNA data. We show that almost all the inhabitants of Europe c...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy180
更新日期:2018-12-01 00:00:00
abstract::The genomics era has expanded our knowledge about the diversity of the living world, yet harnessing high-throughput sequencing data to investigate alternative evolutionary trajectories, such as hybridization, is still challenging. Here we present sppIDer, a pipeline for the characterization of interspecies hybrids and...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy166
更新日期:2018-11-01 00:00:00
abstract::Variola virus is at risk of re-emergence either through accidental release, bioterrorism, or synthetic biology. The use of phylogenetics and phylogeography to support epidemic field response is expected to grow as sequencing technology becomes miniaturized, cheap, and ubiquitous. In this study, we aimed to explore the...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy153
更新日期:2018-11-01 00:00:00
abstract::Viral genome integration provides a complex route to biological innovation that has rarely but repeatedly occurred in one of the most diverse lineages of organisms on the planet, parasitoid wasps. We describe a novel endogenous virus in braconid wasps derived from pathogenic alphanudiviruses. Limited to a subset of th...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy148
更新日期:2018-10-01 00:00:00
abstract::The rate of recombination impacts on rates of protein evolution for at least two reasons: it affects the efficacy of selection due to linkage and influences sequence evolution through the process of GC-biased gene conversion (gBGC). We studied how recombination, via gBGC, affects inferences of selection in gene sequen...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy149
更新日期:2018-10-01 00:00:00
abstract::Among mammals, several lineages have independently adapted to a subterranean niche and possess similar phenotypic traits for burrowing (e.g., cylindrical bodies, short limbs, and absent pinnae). Previous research on mole-rats has revealed molecular adaptations for coping with reduced oxygen, elevated carbon dioxide, a...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy161
更新日期:2018-10-01 00:00:00
abstract::The mutation rate of an organism is influenced by the interaction of evolutionary forces such as natural selection and genetic drift. However, the mutation spectrum (i.e., the frequency distribution of different types of mutations) can be heavily influenced by DNA repair. Using mutation-accumulation lines of the extre...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy134
更新日期:2018-10-01 00:00:00
abstract::The relative evolutionary rates at individual sites in proteins are informative measures of conservation or adaptation. Often used as evolutionarily aware conservation scores, relative rates reveal key functional or strongly selected residues. Estimating rates in a phylogenetic context requires specifying a protein su...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy127
更新日期:2018-09-01 00:00:00
abstract::Noncoding DNA sequences, which play various roles in gene expression and regulation, are under evolutionary pressure. Gene regulation requires specific protein-DNA binding events, and our previous studies showed that both DNA sequence and shape readout are employed by transcription factors (TFs) to achieve DNA binding...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy099
更新日期:2018-08-01 00:00:00
abstract::Dissecting the evolutionary genetic processes underlying eye reduction and vision loss in obligate cave-dwelling organisms has been a long-standing challenge in evolutionary biology. Independent vision loss events in related subterranean organisms can provide critical insight into these processes as well as into the n...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy106
更新日期:2018-08-01 00:00:00
abstract::Phenotypic plasticity results in a diversity of phenotypes from a single genotype in response to environmental cues. To understand the molecular basis of phenotypic plasticity, studies have focused on differential gene expression levels between environmentally determined phenotypes. The extent of alternative splicing ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy095
更新日期:2018-08-01 00:00:00
abstract::Horizontal gene transfer (HGT) can equip organisms with novel genes, expanding the repertoire of genetic material available for evolutionary innovation and allowing recipient lineages to colonize new environments. However, few studies have characterized the functions of HGT genes experimentally or examined postacquisi...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy082
更新日期:2018-08-01 00:00:00
abstract::Selenium (Se), a sparse element on earth, is an essential micronutrient in the vertebrate diet and its intake depends on its content in soils and waters worldwide. Selenium is required due to its function in selenoproteins, which contain selenocysteine (Sec), the 21st amino acid in the genetic code, as one of their co...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy070
更新日期:2018-07-01 00:00:00
abstract::Genome and transcript sequences are composed of long strings of nucleotide monomers (A, C, G, and T/U) that require different quantities of nitrogen atoms for biosynthesis. Here, it is shown that the strength of selection acting on transcript nitrogen content is influenced by the amount of nitrogen plants require to c...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy043
更新日期:2018-07-01 00:00:00
abstract::Fish mitochondrial genome (mitogenome) data form a fundamental basis for revealing vertebrate evolution and hydrosphere ecology. Here, we report recent functional updates of MitoFish, which is a database of fish mitogenomes with a precise annotation pipeline MitoAnnotator. Most importantly, we describe implementation ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy074
更新日期:2018-06-01 00:00:00